বৃহস্পতিবার, ৯ মে, ২০১৩

Biologist maps the family tree of all known snake and lizard groups

May 8, 2013 ? A George Washington University biologist and a team of researchers have created the first large-scale evolutionary family tree for every snake and lizard around the globe.

The findings were recently published in the journal BMC Evolutionary Biology. Alex Pyron, the Robert F. Griggs Assistant Professor of Biology in GW's Columbian College of Arts and Sciences, along with researchers from the City University of New York and Arizona State University, detail the cataloging of 4,161 species of snakes and lizards, or squamates.

"Squamates include all lizards and snakes found throughout the globe, including around 9,500 species on every continent except Antarctica, and found in most oceans," said Dr. Pyron. "This is everything from cobras to garter snakes to tiny geckos to the Komodo Dragon to the Gila Monster. They range from tiny threadsnakes that can curl up on a dime to 10 feet monitor lizards and 30 foot pythons. They eat everything from ants to wildebeest."

The evolutionary family tree, or phylogeny, includes all families and subfamilies and most genus and species groups, said Dr. Pyron. While there are gaps on some branches of the tree, the structure of the tree goes a long way toward fully mapping every genus and species group.

"It's like building an incomplete family tree for your family, but with half of the 'children' sampled. You're in it, but not your brother, one of your cousins is, but not another. However, because it's so complete, we know where the missing relatives go because there's no longer as much mystery as to how the missing species, or cousins, are related, with a few notable exceptions for some remaining species.

"This is also a community effort. We sequenced hundreds of these species ourselves but took thousands more from public databases, building on the work of others."

Understanding how various snakes and lizards are connected to each other fills a major gap in knowledge, said Dr. Pyron, because before this, there were no single reference for how all lizards and snakes were related or what their classification was.

"A phylogeny and taxonomy is fundamental for all fields of biology that use lizards and snakes, to understand how to classify the species being studied, to interpret biological patterns in terms of relatedness, and even at a more basic level, to count how many species are in an area, for example, for conservation management purposes."

This project has been in the works since 2008 with the last five years being the most intense. It was funded by the National Science Foundation Postdoctoral Research Fellowship in Biological Informatics.

The researchers used DNA sequencing technology to genotype, or identify, the DNA of thousands of lizards and snakes.

"We have laid down the structure of squamate relationships and yet this is still the beginning," said Dr. Pyron. "As hundreds of new species are described every year from around the glove, this estimate of the squamate tree of life shows us what we do know, and more importantly, what we don't know, and will hopefully spur even more research on the amazing diversity of lizards and snakes."

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/nStTdIeX1pc/130508172227.htm

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Movie review: ?Upstream Color? | UWIRE

Posted on09 May 2013.

By: Joe Kleinschmidt

Shot on 16 mm film on a mere $7,000 budget, 2004?s ?Primer? stands among the brainiest sci-fi movies ever made. But the technical story didn?t depend on a multi-million dollar Michael Bay budget ? the director even filmed most scenes in one take. Jargon-laden dialogue made for a dense but rewarding script about a time-travel device that goes awry.

Nearly ten years later, former engineer Shane Carruth returns with a film even more puzzling, although the information lies in the experimental filmmaking instead of the script. Taking cues from Terrence Malick?s playbook, ?Upstream Color? depends on the non-verbal cues of its actors and repetition of parallel imagery to drive the narrative.

But unlike ?The Tree of Life,? Carruth aims for a darker, microscopic approach to the story. Equally disorienting and emotionally palpable, a man abducts Kris, an effects artist (Amy Seimetz). The mysterious figure uses a bioengineered grub to manipulate her. After a grisly surgery involving a pig, Kris recovers with no memory.

Eventually, she bonds with a trader named Jeff (Carruth), who shares a similar experience, and the two fall in love in the unspecified dystopia. Detailing the plot of ?Upstream Color? poses problems because the film challenges audiences with fractured shards of information rather than a linear arc.

While the visuals remain arresting throughout the film, the experience feels dependent on your ability to empathize with the stone-faced acting. Many of Carruth?s lines feel stilted, but Seimetz drives the emotional arcs successfully. ?Upstream Color? remains Carruth?s brainchild. And as the producer, writer, director, editor, cinematographer, composer and distributor ? the film secures his position as a true autodidact. ?Primer? wasn?t a fluke.

?Upstream Color? disorients, but for a true purpose. Shards of individual scenes and moments explore humanity?s loss of connection to the natural world. After abandoning an epic adventure, ?A Topiary,? Carruth?s newest, represents his most personal work to date. The barrage of close-ups creates a singular tactile experience alongside a creeping electronic score.

Kris experiences the implanted grub moving throughout her limbs, more gripping than the chest-bursting scene in ?Alien.? On screen, the digital and natural worlds somehow affect one another ? close-ups show an illogical relationship with nature for Kris and Jeff. In one scene, the two recite ?Walden? to each other in between swimming laps.

Ultimately, Carruth aims for Stanley Kubrick?s level of artistry. ?Upstream Color? may fall slightly short, but the confusing experience gives darkly emotional strokes of genius that conventional movies fail to live up to. Carruth fills the movie with tantalizing visual riddles that reward multiple viewings. Even with its shortcomings and deliberate uncertainty, the movie marks the work of an auteur.

?

Where: Walker Art Center, 1750 Hennepin Ave., Minneapolis

When: 7:30 p.m., Friday; 4 p.m. and 7:30 p.m., Saturday

Cost: $7 for students, Walker members and seniors; $9 for the public

Directed by Shane Carruth

Starring Amy Seimetz, Shane Carruth and Andrew Sensenig

Source: http://uwire.com/2013/05/09/movie-review-upstream-color-2/

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Yahoo reportedly wants to kick Microsoft to the curb

On Tuesday, Yahoo reported in a new government filing that it has renewed a search engine revenue deal with Microsoft until March 31, 2014. That agreement is just a small part of Yahoo's overall deal with Microsoft that sees the website using the Bing search engine.

Yahoo CEO Marissa Mayer reportedly doesn't want to deal with Microsoft's Bing search engine anymore

The Yahoo-Bing partnership was signed in 2009, but in more practical terms, started in early 2010. Now Yahoo's current CEO Marissa Mayer is reportedly looking to break the deal well ahead of its 10 year lifespan. The Wall Street Journal, via unnamed sources, claims that Mayer has been trying to cut the Microsoft contract ever since she came on board as CEO in 2012.

However, the report also states that the Yahoo-Bing deal isn't going away anytime soon. Analysts claim the earliest opportunity for the agreement between the two companies to be broken is 2015. Yahoo is within its right to break the contract if the revenue it gets per search goes down below an unspecified level.

The story also claims that the search agreement could be cut off if Microsoft were to sell off its Bing business. What's more interesting is that the article claims Microsoft actually though about doing just that in 2012. There's no other word on why Microsoft would consider such a move nor why they apparently decided against it.

Yahoo could develop its own Internet search technology as a replacement or it could made a similar search engine agreement with Google. Such a deal could run into antitrust issues with the US government, but any such agreement could be structured to avoid such problems.

Source: Wall Street Journal | Image via Yahoo

Source: http://feeds.neowin.net/~r/neowin-main/~3/dA3kEE0_3Ic/story01.htm

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বুধবার, ৮ মে, ২০১৩

ABBA museum? Yes! ABBA reunion? No!

Music

8 hours ago

Stockholm boasts a new attraction that's already drawing crowds to the Swedish capital -- a museum devoted to the city's most successful musical act, ABBA.

Though ABBA disbanded 30 years ago, their popularity endures. Even so, former member Bjorn Ulvaeus, who was instrumental in the museum's development, finds the idea of the project strange.

"It's a bit weird to build a museum of yourself," he told TODAY's Natalie Morales. But he added, "The city of Stockholm has been asking for this for a long time.

Of course, fans of the disco legends have been asking for something for a long time too -- an ABBA reunion.

"I'm the only one who says no then," Ulvaeus mused when it was revealed that his former fellow bandmates are all on board with the idea. "If we really think about it ? oh, well."

"Oh, well? He's not saying no here," Morales responded optimistically.

But Ulvaeus was quick to counter that.

"I am!" he insisted.

Source: http://www.today.com/entertainment/abba-museum-yes-abba-reunion-no-6C9814725

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Obama: North Korea has failed again

President Barack Obama during a joint news conference with South Korean President Park Geun-Hye in the East Room of the White House in Washington, Tuesday, May 7, 2013. (AP Photo/Pablo Martinez Monsivais)

President Barack Obama during a joint news conference with South Korean President Park Geun-Hye in the East Room of the White House in Washington, Tuesday, May 7, 2013. (AP Photo/Pablo Martinez Monsivais)

President Barack Obama and South Korean President Park Geun-Hye during their joint news conference in the East Room of the White House in Washington, Tuesday, May 7, 2013. (AP Photo/Pablo Martinez Monsivais)

President Barack Obama, right, and South Korean President Park Geun-Hye, left, during their meeting in the Oval Office of the White House in Washington, Tuesday, May 7, 2013. (AP Photo/Pablo Martinez Monsivais)

Visiting South Korea President Park Geun-hye, lays a wreath at the Tomb of the Unknowns at Arlington National Cemetery in Arlington, Va., Monday, May 6, 2013. (AP Photo/Manuel Balce Ceneta)

(AP) ? President Barack Obama said Tuesday that North Korea can no longer create an international crisis with nuclear provocations, asserting the United States and South Korea are fully capable of defending themselves.

"The days when North Korea could create a crisis and elicit concessions, those days are over," Obama said from the White House East Room, after he and South Korean President Park Geun-hye met privately in the Oval Office.

Obama's comments came in a news conference with Park on her first foreign visit as the country's leader. It marked the 60th anniversary of the U.S.-South Korean alliance.

Obama said that Pyongyang has failed to drive a wedge between the U.S. and South Korea or to garner global respect with its threats. He says the joint U.S.-South Korea meeting at the White House was evidence that North Korea has "failed again."

Ahead of the meeting, U.S. officials said North Korea has taken a step back from its recent escalation of regional tensions by removing from its launch site a set of medium-range ballistic missiles that had been readied for possible test-firing.

Obama says he doesn't know North Korean leader Kim Jong Un personally and has never spoken to him, but says he can still take a different path. He said actions by the unpredictable young leader, who came to power after the death of his father Kim Jong Il in December 2011, seem to pursue a dead end.

"There's going to have to be changes in behavior," Obama said. "We have an expression in English, 'Don't worry about what I say, just watch what I do.'"

Park arrived at the White House with a color guard lining the driveway from Pennsylvania Avenue. Her Oval Office meeting, working lunch and joint news conference with Obama will be followed Wednesday by an address to a joint meeting of Congress.

Obama said such an address is an honor "reserved for our closest of friends." He called Park "tough," spoke of a great friendship between the two nations and joked that "the Korean wave" of culture has hit the United States.

"My daughters have taught me a pretty good 'Gangnam Style,'" Obama joked, a reference to the hit dance song by South Korean singer PSY that has become YouTube's most watched video with 1.5 billion views since its release last summer.

Park has had something of a baptism of fire since she took office in February, two weeks after North Korea's latest atomic test ratcheted up tensions on the divided Korean Peninsula and undermined her hopes of forging a more trusting relationship with a difficult neighbor.

"Instead of just hoping to see North Korea change, the international community must consistently send the message with one voice, to tell them and communicate to them that they have no choice but to change," Park said.

After the U.N. Security Council tightened sanctions on North Korea in response to the nuclear test ? its third since 2006 ? it claims to have scrapped the 1953 Korean War armistice and has threatened nuclear strikes on the U.S., prompting Washington to bolster missile defenses.

Two Musudan missiles at a site in eastern North Korea had been in what American officials described as launch-ready status for some weeks. Two U.S. officials confirmed their removal on condition of anonymity because they were not authorized to publicly discuss a matter involving sensitive U.S. intelligence. It's not clear why they removed the missiles in recent days, but Pentagon press secretary George Little said on Monday that U.S. officials have seen a "provocation pause" by North Korea.

Park touched down in New York on Monday, meeting first with U.N. Secretary-General Ban Ki-moon, a former South Korean foreign minister who praised her "firm but measured" response to North Korean provocations and determination to resolve their differences though dialogue.

However, Park made clear in an interview on the eve of her visit that she was willing to get tough on North Korea. She told CBS News that if South Korea came under attack, "We will make them pay."

Park, the first democratically elected female leader in Northeast Asia, is no stranger to Seoul's Blue House, as the residence of the chief executive is known. She's the daughter of the late South Korean dictator Park Chung-hee, and in her 20s she took over the duties of first lady for five years after a gunman claiming orders from North Korea killed her mother in a botched attack targeting her father.

While focused squarely on the North Korean threat, Park's visit is a chance to build a rapport with Obama, who enjoyed an unusually close bond with the previous South Korean leader, Lee Myung-bak. The two presided over the adoption of a U.S.-South Korean free trade pact in 2012 that expanded the scope of an alliance largely built on security ties and deterring an attack from the North. Some 28,500 U.S. troops are still based in South Korea for that purpose.

Lee took a hard line on relations with Pyongyang, cutting aid to the impoverished nation. While his approach had Obama's firm backing, public frustration in the South has mounted over the North's continued weapons tests and provocations ??" including attacks in 2010 that left dozens of South Koreans dead.

In a change of tone, Park, although a conservative, has advocated trying to build trust with Pyongyang through aid shipments and large-scale economic initiatives if there's progress on the nuclear issue, even as she and South Korea's military promise to respond forcefully to any possible attack from the North.

But to date, relations have only gotten worse. Most recently, North Korea has withdrawn its 53,000 workers from an industrial park on its territory run by South Korean companies. After Pyongyang rejected Seoul's offer of talks, the South last week withdrew its last staff from the facility, closing the last remaining symbol of inter-Korean cooperation that began during the "sunshine" engagement policy championed by Lee's more liberal predecessors.

On Tuesday, North Korea threatened the U.S. and South Korea over joint naval drills taking place this week in the Yellow Sea. The section of the Korean People's Army responsible for operations in North Korea's southwest said it will strike back if any shells fall in its territory during the drills. Should the allies respond to that, the statement said, Pyongyang's military would then strike five South Korean islands that stand along the aquatic frontline between the countries.

Daniel Russel, White House senior director for Asian affairs, said Obama would reaffirm the U.S. commitment to the defense of South Korea. He said the joint appearance of the two leaders at the White House would make it crystal clear to Pyongyang that the allies stand shoulder to shoulder.

"In dealing with North Korea, it's vital we show unity," Russel told reporters.

Dealing with Pyongyang's secretive regime, never easy, has become increasingly tough under the unpredictable young leader Kim Jong Un, who came to power after the death of his father Kim Jong Il in December 2011.

Russel cautioned it was premature to judge whether North Korea's cycle of provocation "is going up, down or zigzagging." He said both the U.S. and South Korea support "incremental engagement" with Pyongyang, but it has to take "irreversible steps" signaling a commitment to end its nuclear program.

The past year has already seen disconcerting progress in the North's weapons development, including its first successful launch of a three-stage, long-range rocket, although it is not yet believed to have to have the means to fire a nuclear-tipped missile at mainland America.

The Obama administration has put increasing emphasis on the role the North's main ally and benefactor, China, can play to press Pyongyang to honor its previous commitments on denuclearization. In a significant move, one of China's biggest banks said Tuesday it has halted business with a North Korean bank accused by the U.S. of financing Pyongyang's missile and nuclear programs in the latest sign of Beijing's displeasure with its estranged ally.

___

Associated Press writers Robert Burns, Nedra Pickler and Jim Kuhnhenn contributed to this report.

Associated Press

Source: http://hosted2.ap.org/apdefault/89ae8247abe8493fae24405546e9a1aa/Article_2013-05-07-US-US-SKorea/id-583e6a8a427742e3aea5acb5f3f29ebc

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Baxter drug fails to slow Alzheimer's in big study

DEERFIELD, Ill. (AP) ? Baxter International Inc. says that a blood product it was testing failed to slow mental decline or to preserve physical function in a major study of 390 patients with mild to moderate Alzheimer's disease.

The company says that people who received 18 months of infusions with its drug, Gammagard, fared no better than others given infusions of a dummy solution.

Gammagard is immune globulin, natural antibodies culled from donated blood. Researchers thought these antibodies might help remove amyloid, the sticky plaque that clogs patients' brains, sapping memory and ability to think.

Patients with moderate disease and those with a gene that raises risk of Alzheimer's who were taking the higher of two doses in the study seemed to benefit, although the study was not big enough to say for sure.

"The study missed its primary endpoints, however we remain interested by the prespecified sub-group analyses" in groups that seemed to benefit, Ludwig Hantson, president of Baxter's BioScience business, said in a statement.

Gammagard is already sold to treat some blood disorders, and the results of the Alzheimer's study do not affect those uses. About 35 million people worldwide have dementia, and Alzheimer's is the most common type. In the U.S., about 5 million have Alzheimer's. Current medicines such as Aricept and Namenda just temporarily ease symptoms. There is no known cure.

Excitement about Gammagard grew last summer, when researchers reported at a medical conference that the drug had stabilized Alzheimer's disease for as much as three years in four patients who had been receiving the highest dose of it for three years in the study. People typically go from diagnosis to death in about eight years, so to be stable for so long was considered remarkable.

The new results on the full group of study participants are disappointing, said the study's leader, Dr. Norman Relkin, head of a memory disorders program at New York-Presbyterian Hospital/Weill Cornell Medical Center.

"The bar was set very high" for the drug to show improvement, and "there does appear to be a signal" that it helped the two-thirds of patients in the study who had the apoE4 gene that raises the risk of developing Alzheimer's, as well as those with moderate versus mild disease, Relkin said.

No new side effects were seen in the study. About 5 percent of patients on the drug had a rash and decreases in hemoglobin, which carries oxygen in the blood. There were 17 serious reactions, 12 in the drug group and five in the placebo group.

Full results will be presented in July at an Alzheimer's conference in Boston.

Meanwhile, other studies are under way to test drugs earlier in the course of the disease. An experimental drug, Eli Lilly & Co.'s solanezumab, showed some promise in that setting in an earlier study.

___

Marilynn Marchione can be followed at http://twitter.com/MMarchioneAP

Source: http://news.yahoo.com/baxter-drug-fails-slow-alzheimers-big-study-124417671.html

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মঙ্গলবার, ৭ মে, ২০১৩

Chris Kluwe: Gay Rights Advocacy More Important To Me Than Football (VIDEO)

HuffPost Live:

It looks like Chris Kluwe's time with the Minnesota Vikings has come to a close. The team's 8 year punter was cut Tuesday morning, a year before his contract was up. But the reasons behind the move are unclear. Kluwe himself joined HuffPost Live on Monday to discuss.

Read the whole story at HuffPost Live

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Source: http://www.huffingtonpost.com/2013/05/06/chris-kluwe-gay-rights_n_3226104.html

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